Lupus nephritis is one of the most serious manifestations of systemic lupus erythematosus (SLE). Autoimmunity plays a major role in causing lupus nephritis. It means that your own immune system attacks your healthy body tissues and cells mistakenly.
In right condition, your immune system can defeat the foreign harmful substances immediately. However, when it is activated improperly, the immune system will fail to protect your body. As a result, the antibodies produced by immune system attacks your different body parts instead of protecting your body. When your kidneys are involved, it will cause inflammation in filtering units of kidneys, thus leading to lupus nephritis.
If the inflammation is not suppressed, it will cause progressive damage to the filtering units in kidneys. Afterwards, a myriad of symptoms will occur like hematuria and proteinuria.
Cytoxan and other immunosuppressive drugs as well as hormone can suppress the inflammatory response in kidneys temporarily to control symptoms. Therefore, you will have a remission after using cytoxan for a period. However, these drugs can not correct your immune system or restore impaired kidney structure at all. As your creatinine and 24 hour protein in urine is high, it indicates that your renal function has been damaged severely. Therefore, to treat your disease effectively and completely, the therapy should be able to suppress the inflammatory response in your kidney, correct your immune system and restore your impaired kidney structure.
Immunotherapy is an alternative therapy for lupus nephritis. It has the above curative effects and can stop your disease from progressing effectively.
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