Diabetes is hard to manage. You can get a comprehensive understanding of the disease here and get the information about the latest treatments and get professional advices. read more
Micro-Chinese Medicine Osmotherapy is a brand-new therapy based on traditional Chinese herbal medicines dating back thousands of years ago. It combines the essences of herbal medicines read more
Hormonal therapy is commonly used to treat Kidney Disease in clinic. It refers to use one or more than one hormone medicines to suppress the over-reactive immune reaction read more
Patients are suggested to treat kidney disease first before they get pregnant read more
If you are diagnosed with Kidney Disease, you should talk to your doctor about starting an exercise read more
Foods and Drinks play an important role in Kidney Disease patients read more
Kidney Disease News and Events read more
In every week, a famous experienced renal medicine specialist will be invited to help diagnose and evaluate inpatient's disease condition, offering detailed therapeutic schedule. read more
Chronic Allograft Nephropathy (CAN) is the leading cause of kidney transplant failure and occurs moth to years after the transplant. When it occurs, the renal function will decline gradually. As a result, elevated creatinine level will occur. What are the risk factors of chronic allograft nephropathy?
Donor age explains approximately 30% of the variance in graft outcome beyond one year. A relative deficiency in the number of nephrons vis-a-visa the recipient’s metabolic demands.
Prolonged ischemic exposure
After Kidney Transplant, if the new kidney stays in ischemic state for too long, it also cause inferior long-term outcome.
Acute rejection episodes
Acute rejection is a significant cause of failure of kidney transplant. It can cause the new kidney to failure in several days.
Kidney rejection episodes that occur months or years after kidney transplant are at a high risk of evolving into chronic allograft nephropathy.
Elevated cholesterol levels
Hypertriglyceridemia is an independent risk factor of late graft loss.
High blood pressure
Recipient hypertension protends a poorer outcome with a faster decline in function and a grater likelihood of return to dialysis compared with patients with a normal blood pressure.
The above are risk factors of chronic allograft nephropathy. Once the new kidney loses its normal function, creatinine and other metabolic wastes will build up in body, leading to elevated creatinine.
To lower elevated creatinine in chronic allograft nephropathy, firstly it is important to eliminate the causes of failure of the new kidney. It can help stop the further damage to kidney.
Elevated creatinine level indicates that about 50% of your renal function has been lost. If left uncontrolled, new kidney transplant will have to be performed soon. To lower elevated creatinine level in chronic allograft nephropathy, the key treatment step is to restore impaired kidney structure and improve renal function. If the renal function can be improved, another Kidney Transplant will not be necessary.
For more information on chronic allograft nephropathy, please consult us on line.