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How to Make a Diagnosis of FSGS in the Early Stage


2012-10-10 15:45

Focal Segmental Glomerulosclerosis, or FSGS, occurs when scarring impairs the kidney's ability to filter blood. While no age group is exempt, primary FSGS is often diagnosed in individuals 18-45 years of age. Men are affected more frequently than women. Here, we'd like to talk about how to make an early diagnosis of FSGS.

The early stage of glomerular disease may cause no symptoms. Other than routine urine and blood tests, immune special tests can help us make an early diagnosis of FSGS. They include:

▪ Kidney Damage Test

Aims: 1) confirm the kidney damage; 2) the damaged part, glomerulus or renal tubules; 3) make the severity of kidney damage clear and guide the clinical choice of medicine; 4) judge patient's sensitivity to medicines and guide the clinical medicine application.

Checking items include: UTP, U-malb, U-TRF, U-IgG, β 2-microglobulin, α1-microglobulin, α2-macroglobulin, κ light chain, λ light chain, U- NAG, U-GGT, and Uosm.

▪ Toxins in Blood Test

Aims: 1) Make the buildup of toxins in the body clear; 2) guide the choice of immune clearance method.

Checking items include: BUN, Creatinine, UA, β 2-microglobulin, Cyc C, RBP, HCY, and PTH.

▪ Complement in Blood Serum Test

The tests include C3, C4, CH50, C3B etc. They serve to help your doctors to hold a clear overview of classical pathway and specific pathway of complement, which can deal with the underlying immune disorder.

A person who has just received a diagnosis of FSGS may reach ESRD within a variable period of time; it can be a year, it may take 10 years or more. However, prompt treatment will prolong kidney function for as long as possible, or may even reverse the condition.




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