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Differential Diagnosis of FSGS and Minimal Change Disease (MCD)


2012-10-16 10:50

FSGS is increasing in incidence in adults and children, and in the United States, in adults, is now the most common cause of Nephrotic Syndrome. While, Minimal Change Disease (MCD) accounts for greater than 90% of cases of children NS. Here, we will talk about differential diagnosis of FSGS and MCD.

Both of the disease have some common things, but we can distinguish them according to some important differences.

1. FSGS can affect people of all ages, while MCD mostly occurs in children.

2. Sometimes, FSGS respond to steroid treatment; while MCD usually responds well to treatment with high dose of prednisolone (steroids).

3. FSGS patients' kidney function may be damaged, and may get worse gradually. The disease can cause complete kidney destruction which requires dialysis or a Kidney Transplant. FSGS may recur after a transplant. MCD doesn't impair the kidney function.

4. In FSGS, immunofluorescence may show non-specific entrapment of IgM and C3 in sclerotic areas or areas where mesangial matrix is increased. Immunofluorescence studies are typically negative in MCD. Under the electron microscopy, both of diseases show foot process effacement. In FSGS, foot process effacement is often not complete. Foot process effacement in MCD is typically extensive.

The above is about differential diagnosis of FSGS and MCD. To have a precise diagnosis of the disease, clinical manifestations, pathological changes based on lab exams, medical history, and other associated information should be taken into consideration. Effective treatment can ensure a better outcome. If you are interested to learn more about FSGS, leave a message in the below or Email to kidneyabc@hotmail.com.



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