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The hepatitis B virus (HBV) infection is a profound global problem and an important cause of secondary glomerular diseases. In this text, we will introduce some facts that you should know about Renal Disease & HBV.
Numerous renal diseases are associated with hepatitis B, including MPGN type I and III, IgA Nephropathy, mesangial proliferative GN, minimal change disease (MCD), and FSGS. The most common kidney disease associated with HBV is Membranous Nephropathy (MN).
The clinical manigestations of HBV-related MN in pediatric and adult patients are slightly different.
1. There is a strong male preponderance in children in pediatric HBV-related MN and Nephrotic Syndrome is the most frequent presentation. A small proportion experience microscopic hematuria with normal or mildly impaired renal function. Pediatric carriers of chronic HBV often do not have overt liver disease, and transaminase levels are often normal.
2. For adult patients, the most common manifestations are the nephrotic syndrome or protein in the urine. Compared with pediatric patients, the preponderance of occurrence in adult males is less obvious. In addition, adults are more prone to present high blood pressure, renal dysfunction and clinical evidence of liver disease than children.
For childhood disease, there is a high rate of spontaneous remission, but adults with HBV-related MN typically undergo a progressive course of the disease. Therefore, the treatment patients find for Hepatitis B and Kidney Disease should help achieve these purposes: amelioration of NS and associated complications, such as hyperlipidemia, edema, infection as well as preservation of the renal function. Based on your individual disease condition, specific treatment methods can be prescribed to ensure satisfactory curative effects.
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