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Hepatitis C Virus ( HCV) And Chronic Kidney Disease (CKD)

Provided by Expert Zhang Youkang on 2013-07-06 09:32

Hepatitis C virus (HCV) is both a cause and complication of chronic kidney disease (CKD).This infection also brings a big challenge for people with dialysis and with kidney transplant.How does hepatitis C virus (HCV) CKD?

Causes of CKD in HCV

Direct mesangial injury by HCV

HCV RHA and related proteins bind to mesangial cells, tubular epithelial cells, and endothelial cells of glomerular and tubular capillaries.The HCV-related proteins in the mesangium may cause the inflammation in kidneys. It is a possible cause of mesangial injury.

Systemic immune response

Cryoglobulins,HCV-antibody immune complexes, or amyloid deposition can lead to an abnormal the systemic immune response. The abnormal immune system activity can cause inflammation in kidneys, leading to kidney injury.

Higher prevalence of Diabetes

Another possible mechanism underlying HCV-related CKD is nonimmunologically mediated.HCV-positive patients have elevated levels of fasting serum insulin and resistance, and high prevalence of diabetes. Diabetes is one of leading causes of CKD in clinic.

Treatment for HCV induced CKD

Hypertension, proteinuria, and progressive renal failure are the main clinical manifestations of HCV-associated CKD. Blood pressure medications and antiproteinuric agents should be applied to control these conditions. Diuretics, renin–angiotensin system inhibitors (either angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers), and eventually lipid-lowering agents, have been proven to be beneficial in HCV patients with CKD.

Additionally, antiviral and immunosuppressive therapy is also be used to control and virus infection and the abnormal immune system activity in kidneys.

Both HCV itself and HCV induced CKD are very difficult to manage.The above conventional treatments are far enough to control the condition. Immunotherapy is an alternative treatment for HCV induced CKD.This therapy can control the abnormal immune system activity in kidneys and help the body rebuild normal immune system. Along with the regular treatment for HCV, the patients with HCV induced CKD can achieve a better treatment outcome.

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