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HBV Associated Kidney Disease and Kidney Transplant

Provided by Expert Zhang Youkang on 2012-10-22 18:10

HBV associated kidney disease is a kidney disorder which is caused by HBV. Kidney Transplant usually is the last choice for many patients.

HBV associated kidney disease

Kidney disease is a common complication of chronic hepatitis B virus (HBV) infection. The uncommon occurrence, variability in renal histopathology, and heterogeneity in clinical course present challenges in clinical studies and have resulted in a relative paucity of data and uncertainty with regard to the optimal management of HBV-related glomerular diseases.

Can kidney transplant cure HBV associated kidney disease?

The advent of nucleotide analogue medications that effectively suppress HBV replication has markedly altered the clinical outcomes of kidney transplant recipients with HBV infection, but the emergence of drug resistance is an escalating problem.

Can kidney transplant cure HBV associated with kidney disease? Unluckily, the answer may be no. HBV associated kidney disease not only results from the kidney damages. More important, it is caused by the immune disorder. However, kidney transplant cannot deal with the immune problem.

HBV The easiest way to understand immune evasion by HBV is to look at individuals with chronic HBV. Individuals presenting with chronic HBV infection demonstrate diminished CD4+ and CD8+ T-cell responsiveness. It is suspected that low T-cell levels result from high levels of HBeAg, a secretory form of the nucleocapsid antigen, whose function in HBV infection is not well understood. Because HBeAg is not required for viral infection, replication, or assembly, but is still found in all hepadnaviruses, researchers believe that it may have a role in viral persistence.

Kidney transplant only replaced the failed kidneys to work and remove the toxins and waste products out of the body. It cannot regulate your immune system. And even with transplanted kidney, you still have the risk to develop HBV. And once it is triggered, possibly HBV associated kidney disease will come to you again.

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