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Hepatitis B Virus (HBV)-associated Glomerulonephrits

HBV Kidney Disease basics

Definition

Hepatitis B virus(HBV)-associated Glomerulonephritis is a kind of glomerulonephritis caused by hepatitis B virus directly or indirectly. It can cause the inflammation in glomeruli and damage their normal function. As a result, a large amount of protein pass through glomeruli and end up in urine.

Causes

HBV-associated Glomerulonephrits is mainly attributable to the following causes.

* HBV antigens combine with the relative antibodies to form immune complexes. The complexes can flow in blood and then deposit in glomeruli and tubule, thus leading to kidney damage.

* HBV can infect renal functional cells and tissues directly. Apart from kidney, the virus also can infect other body parts like skin, bone marrow and epithelium of bile duct.

* HBV can cause immune dysfunction and cause immune injury to kidneys.

Symptoms

* Children with HBV-associated Glomerulonephritis commonly develop Nephrotic Syndrome, microscopic hematuria. Also, approximately 75% of them develop high blood pressure.

* Most of adults with HBV-associated Glomerulonephrits had a medical history of hepatitis. Generally, they may develop kidney disease within 6 months after the onset of the disease. They mainly present reduced urine output, swelling, hematuria, proteinuria and high blood pressure.

Health care

*If the patients with renal high blood pressure, they should monitor their blood pressure regularly and reduce high blood pressure to 130/80mmHg.

* Develop a kidney diet. If they have renal insufficiency, they should keep a high-calorie diet, low high-quality diet and limit the intake of fluids.

* If the patients have serious swelling, they may have short breath and even can not lie on back. To reduce the discomforts, they can adjust their body gesture to make them feel better.

If you have been diagnosed with HBV Kidney Disease, we're here to help. Call us: US +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

HBV Kidney Disease symptoms

Hepatitis B virus(HBV)-associated Glomerulonephritis is secondary to hepatitis B. It mainly occurs among teenagers. However, many patients with hepatitis usually only care about the tests for aminopherase, but often neglect routine urine test, tests for renal function and blood pressure. Early inspection can help the patients find kidney damage as early as possible. It is important to reduce and even prevent kidney damage. The symptoms of HBV-associated Glomerulonephritis vary among children and adults.

Children HBV-associated Glomerulonephritis

※It mainly occur at age 2~12 and the average age of onset is 6.

※ Most of the children develop Nephrotic Syndrome featured with heavy proteinuria, swelling, hypoproteinemia and hyperlipidaemia. As the virus and complexes cause inflammation in glomeruli, they will lose the normal filtering and barrier function. As a result, a large amount of protein pass through glomerular basilar membrane and end up in urine.

※ Microscopic hematuria( blood in urine) are commonly seen and gross hematuria is rarely seen. This is because the red blood cells leak into urine once the glomerular structure is damaged.

※ About 75% of children have high blood pressure, but only a minority have the presentations of Renal Failure.

Adults with HBV-associated Glomerulonephritis

※Most of adults with HBV-associated Glomerulonephritis have medical history of acute hepatitis. Generally, they may develop kidney disease within 6 months after the onset of the disease.

※ If they do not have hepatitis history, but have moderate live function abnormality or aminopherase abnormality or typical chronic active hepatitis, they may not have presentation of kidney disease or only have mild presentation.

※ The adults mainly present reduced urine output, swelling, hematuria, proteinuria and high blood pressure.

Among both children and adults with hepatitis B, no matter how mild the symptoms are, there still are deposits like IgG, C3, IgM and IgA in glomeruli. This implies that they may have developed HBV-associated Glomerulonephritis.

If you have been diagnosed with HBV Kidney Disease, we're here to help. Call us: US +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

HBV Kidney Disease treatment

HBV-associated Glomerulonephritis is secondary disease of hepatitis B. Experiences show that routine treatment alone is not enough to manage the disease at all. The latest treatment for HBV-associated Glomerulonephritis is believed to be immunotherapy.

Kidney damage in hepatitis is attributable to the following factors. The hepatitis B can damage kidney tissues and cells directly, thus resulting in impairing kidneys. On the other hand, when hepatitis B virus invades into body, it can stimulate immune system to produce relative antibodies. The hepatitis B antigens combine with antibodies to form immune complexes in blood. The immune complexes can enter kidneys and deposit in blood vessels. To remove them, the body initiates an inflammation which can impair glomeruli.

Immunotherapy is not a single treatment method. The types of immunotherapy used in treating HBV-associated Glomerulonephritis mainly include:

Immune blocking

Immune blocking is designed to suppress the immune inflammatory response effectively and quickly. In this way, it can stop further immune injury to kidney tissues and cells.

Blood purification

Blood purification is used to remove various pathological substances from your body. It includes hemoperfusion, hemofiltration, plasma exchange, etc and each of them can filter one or more than one specific toxins in the blood. For example, plasma exchange has a powerful function in removing immune complexes and antibodies in blood. Hemofiltration focuses on removing the middle sized wastes and toxins from body. These blood purification methods can cooperate well to clear up the immune complexes and hepatitis B virus completely.

Micro-Chinese Medicine Osmotherapy

When hepatitis B virus and immune complexes are removed from blood, the trigging factors of kidney damage is eliminated. How about the already impair kidney function?

Micro-Chinese Medicine Osmotherapy plays the vital role in this step. On one hand, it can degrade the immune deposits in kidneys which can not be removed by blood purification. On the other hand, the effective medicine ingredients can activate the regeneration of impaired kidney cells and cells to restore the renal function.

The above are the main types of Immunotherapy in treating HBV-associated Glomerulonephrits.Based on your individual illness condition, more treatment methods may be prescribed by your doctors.

If you have been diagnosed with HBV Kidney Disease, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

HBV Kidney Disease diagnosis

HBV-associated Glomerulonephritis is a hard and complex condition to treat because it involves kidney damage, liver impairment and immune system dysfunction. Therefore, the routines tests alone are not enough to give a clear diagnosis of the disease. The following tests and procedures are usually ordered to the patients.

* Routine blood tests

This test mainly includes total Total Count, Differential Count, Erythrocyte Sedimentation Rate and Hemoglobin.Total Count determines the amount of white blood cells in the blood. When there is infection, the Total Count will exceed 10,000/cubic mm of blood. Differential Count and this test aims testing the consistency of the white blood cells. Erythrocyte Sedimentation Rate. This tests the value of red blood cells. Hemoglobin tests the amount of red blood cells. Abnormal amount can signify anemia.

* Routine urine tests

Routine urine tests include the tests for urine color, clarity, odor, specific gravity and the levels of pH, protein, glucose, nitrites, and red and white blood cells.

The tests can screen for Kidney Disease and also can help figure out the damaged sites of kidneys like glomeruli or renal tubule.

* Kidney damage tests

Kidney damage tests help to figure out whether your kidneys are damaged and the kidney damage degree. Also, it can evaluate if you are sensitive to medicines.

The tests mainly include U-TP, U-malb, U-TRF, U-IGG,β2-M, α1-M etc.

* Toxins in Blood Tests

The tests aim to figuring out the type and amount of toxins in blood mainly including BUN, CR, UA, BMG, CycC, RBP, HCY, IL-6, PTH etc.

The test results can guide your doctor to find a right treatment option.

* HBV-DNA

If the tests turn positive, it tells the HBV duplication and infection.

The above are main tests which are ordered to diagnose HBV-associated Glomerulonephritis. Early and accurate inspection and diagnosis can help reduce kidney damage and improve the prognosis of the disease remarkably.

If you have been diagnosed with HBV Kidney Disease, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

HBV Kidney Disease knowledge

Marriage

Hepatitis B can be infectious, but the kidney damage caused by this disease will not infect others. People with Hepatitis B Virus-associated Nephropathy can get married. Patients with the disease are suggested to inform his/her companion that they have the disease before they get married. Then, they can take precautions against this disease in advance.

Before the marriage, the healthy partner should inject Hepatitis B vaccine. Then they can get married after the production of antibody against Hepatitis B within the body.

Sexual Life

In clinic, Hepatitis B Virus-associated Nephropathy is very difficult to cure. We all know that the transmission of Hepatitis B is mainly through blood, but it can transmit through intimate contact such as sex.

Patients who have normal kidney function can have moderate sexual activity, but the frequency should be limited. Patients accompanied with high blood pressure should shorten the length of sex each time. If the disease condition is not stable, patients are not suggested to have sex, which may worsen patient's condition.

Pregnancy

The hereditary incidence of Hepatitis B virus can be as high as 30 to 90 percent. Without effective precautions, more than 90 percent of children will get infected.

People with Hepatitis B Virus-associated Nephropathy are suggested to get pregnant after their disease condition keeps stable, urine test maintains normal, and the renal function has kept normal. During the pregnancy period, maximally lowering the amount of virus within the mother's body can help reduce the baby's chance to get infected.

If you have been diagnosed with HBV Kidney Disease, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

HBV Kidney Disease healthcare

Hepatitis B Virus-associated Glomerulonephritis is a hard disease to deal with, because it combines hepatitis B and renal disease together, both of which are difficult to treat. Therefore, you should take your daily health care more seriously.

▪ Diet.

Eat more fruits and vegetables to give ample vitamin and fibrin. These foods can also boost digestive function.

Keep a low-fat diet. You can replace animal oil with vegetable oil and had better not by prepared foods that contain artificial fats. Also, extra sugar can convert to fat in body so it is necessary for you to limit the sugar intake.

Limit the intake of foods loaded in nucleoprotein and even avoid them completely. Bean and bean products should be avoided.

Restrict the amount of foods that you are taking. If you take too much foods, it can put much burden on liver and other organs.

Alcohol is absolutely forbidden for the patients with HBV-associated Glomerulonephrits.

Have a restrict control of foods high in proteins and choose foods containing essential amino acids instead of unessential amino acid.

▪ Mental Health

Patients always feel depressed due to long course and easy recurrence of kidney disease. It is very important to encourage them to establish the confidence to defeat the disease and keep a positive attitude toward good recovery.

▪ Daily Life

-Prevent infections and other triggers;

-Do regular exercise and improve the body's resistance;

-Have regular check-ups.

While observing the principles of health care for chronic kidney disease, patients had better also follow the health care of hepatitis disease. Only in this way, can they have the best recovery.

If you have been diagnosed with HBV Kidney Disease, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

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