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Proteinuria Can Worsen the Prognosis of IgA Nephropathy

2013-07-02 14:36

iga nephropathy, proteinuriaIgA Nephropathy is an autoimmune disorder.It occurs when the immune globulin A ( IgA) lodges in kidneys.IgA nephropathy is the most common lesion causing primary glomerulonephritis in the world.How is the prognosis of IgA nephropathy?

The prognosis of IgA nephropathy is variable.About 25 percent of adults with IgA nephropathy develop total kidney failure.Only 5% to 10% of children develop total Kidney Failure.Proteinuria is a significant factor in worsening the prognosis of IgA nephropathy.

Patients with IgA nephropathy and little or no proteinuria(< 500 mg/day) have low risk of progression in the short term, while the rate of decline in renal function is 25-fold faster in those with sustained proteinuria>3g/d. Therefore,control of high blood pressure and proteinuria can slow the progression of IgA significantly.How to control proteinuria in IgA nephropathy becomes a major concern for the patients.

Firstly, two types of blood pressure medicines called angiotensin-converting enzyme(ACE) inhibitors and angiotensin receptor blockers(ARBs) protect can protect renal function.These medicines not only can lower blood pressure, but also can decrease the loss of protein in the urine. However, the pregnant women are not allowed to use these medicines as they may harm the fetus.

Medicines such as prednisone can help treat IgA nephropathy and proteinuria.They can suppress the abnormal immune response,thus relieving proteinuria to some extent.

The above treatments can lower proteinuria and improve the prognosis of IgA nephropathy, but they are far enough to stop the disease progression.

Immunotherapy is an alternative treatment for IgA nephropathy. This therapy can correct the abnormal immune system and help the body rebuild normal immune system.Thus,it can stop further immune damage to kidneys. Additionally,it can stimulate the self-regeneration of impaired kidney tissues to enhance renal function. In this way, the prognosis of IgA nephropathy will be improved remarkably.

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