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IgA Nephropathy

iga nephropathy basics

What is IgA Nephropathy?

The primary type of IgA Nephropathy (or IgAN, Berger's disease) is an immune-complex-medicated glomerulonephritis defined by the presence of IgA deposits in the mesangial area of the kidney.

Immunoglobulin A (IgA) plays a role in mucosal immunity and is produced in mucosal linings. Hence, it can be found in mucous secretions such as tears, saliva, secretions from the gastrointestinal tract, etc. It is found only in small amounts in blood.

The onset of IgAN can be associated with the upper respiratory tract infection, and the disease may occur due to the hyperactivity of the mucosal immune system.

When you get an infection, antigens (a virus, bacteria, or toxin) can easily invade into your body, the body sends out antibodies, which are immunoglobulins produced by the immune system, to fight against these invaders.

However, antibodies fail to fight off these antigens, but lock onto the surfaces of foreign substances, forming antigen-antibody aggregates known as immune complexes. Normally, these objects will circulate through the blood stream until being removed by the liver and other organs. In IgAN, however, they become deposited, or lodged in the tiny filters of the kidney-glomeruli.

These deposits don't belong to our body, so the body will try to eliminate them. The immune complexes are too stubborn to be cleared away, so the inflammatory response will become more and more tense, eventually resulting in hypersensitivity. The renal intrinsic cells and tissues will be impaired if the hypersensitivity is out of control. Symptoms will occur over time.

Causes of IgA Nephropathy

1. Infection and Inflammatory reaction

The attack of IgAN is often followed by an infection, especially infection of the upper respiratory tract. Infection will cause inflammatory reaction inside the body which affects mesangial cells, resulting in secretion of inflammatory cytokines. Finally, massive immune complexes accumulate in the mesangial area of kidney.

2. Genetic predisposition

Researches showed that a part of IgAN patients exhibit familial aggregation of the disease, which indicated that IgAN may inherit.

3. IgA deposition in the mesangial area

Deposition of IgA and other immune complexes in the mesangial area destroy the normal structure of certain renal intrinsic cells, thus causing kidney damage.

If you have been diagnosed with IgA Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

Symptoms for IgA Nephropathy do not occur at the beginning stages of the disease. The disease is a progressive condition, so it can take decades before patients present any symptoms. In some cases, the doctor may detect signs of this disorder during a routine screening. Signs and symptoms of IgA Nephropathy include:

iga nephropathy symptoms

·Cola- or tea-colored urine caused by blood in the urine, or hematuria

·Pain in the sides, flanks, abdomen, or loins

·Foamy or bubbly urine due to protein in the urine, or proteinuria

·High blood pressure

·Low-grade fever

·Fatigue

·Swelling (edema) of the hands and feet

·Flu and cold-like symptoms

·Mood swings

·Becoming more susceptible to allergies

·Lack of response to cold temperatures (mainly in children)

·Urinary tract infections (mainly in young girls)

It is common for people to have IgA Nephropathy for years without developing signs or symptoms and without knowing they have the disease. If you have some of the above signs and symptoms, see your doctor to discuss what might be causing them.

If you have been diagnosed with IgA Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

iga nephropathy treatment

IgA Nephropathy (Berger's disease) is a relatively common kidney disease that affects millions of people worldwide. IgA is a protein produced by the immune system of the body to help fight infection. In IgA Nephropathy, this antibody deposits in the mesangium of glomeruli and causes inflammation and scarring in the kidney.

Treatment should focus on removing IgA immune complexes, blocking further decline of kidney function, as well as recovering the overall kidney function maximally.

1. Symptomatic treatment

Control blood pressure and limit the amount of protein in the urine. Medicines including ACE inhibitors and ARBs can help us achieve both of these purposes.

Corticosteroids, other immunosuppressive drugs, and fish oil have also been used to treat this disorder.

Limit the intake of salt and fluids to control swelling. In some cases, a low to moderate protein diet may be recommended.

People who have progress to end-stage renal failure have to adopt one renal replacement therapy to sustain life: dialysis or kidney transplant.

Though the symptoms of IgA Nephropathy can be alleviated with the above symptomatic treatments, the disease often relapses easily.

2. Holistic treatment-Immunotherapy

Nowadays, immunology has become the most popular research all over the world. Recent study shows that IgA Nephropathy is an auto immune disease causing by immune dysfunction. In this case, immune complex can be produced and deposit in the kidneys, launching a series of pathological changes.

Based on many years' clinical practices, Immunotherapy comes into being as the newest treatment for IgA Nephropathy in China. The whole process can be divided into six steps:

1. An accurate diagnosis. A comprehensive diagnosis and evaluation of each patient's present illness condition is necessary to guide the best treatment plan.

2. Immune blocking. The immune inflammatory response will be restrained rapidly with a set of immune blocking therapeutic methods.

3. Immune clearance. By means of immunosorption, plasmapheresis and blood purification, etc, the harmful substances in the blood can be eliminated completely.

4. Immune tolerance. Though inflammatory damages of tissue and cells caused by immune response have been prevented by immune blocking, the damaged renal inherent cells and immune complexes haven't been removed. It is necessary to help patients adapt this fact. Meantime, regular immune blocking should be adopted.

5. Immune adjustment. On the one hand, immune complex can be cleared away by Traditional Chinese Medicine. On the other hand, we put stress on improving the immunity of the whole body.

6. Immune protection. The integrated of Chinese and western medicine are used to protect and repair the damaged renal tissue and inherent cells. Meanwhile, the immune system will get regulated gradually.

Immunotherapy can treat IgA Nephropathy from the root cause and prevent the relapse. Patients should keep in mind that systemic and consistent treatments are essential to your recovery.

If you have been diagnosed with IgA Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

iga nephropathy diagnosis

If you are suspected to have IgA Nephropathy, you may need to undergo one or more of the following tests.

1. Conventional diagnostic tests

Urine test. As the first sign of IgA Nephropathy, blood or protein in the urine may be discovered as part of a routine checkup. When you are suspected to have kidney problems, it is necessary for you to collect your urine for a 24-hour period for further kidney function tests.

Blood tests. For people with the disease, after doing the blood test, you can observe increased levels of the waste product creatinine in your blood. Occasionally, the IgA level in your blood is also elevated.

Kidney biopsy. The only way to confirm a diagnosis of IgA Nephropathy is with a kidney biopsy. A special biopsy needle is used to extract small pieces of kidney tissue for microscopic examination to determine whether there are IgA deposits in the glomeruli.

2. Immune special examination and diagnosis

▪ Series of Kidney Damage Tests. Aims: 1) confirm the kidney damage; 2) the damaged part, glomerulus or renal tubules; 3) make the severity of kidney damage clear and guide the clinical choice of medicine; 4) judge patient's sensitivity to medicines and guide the clinical medicine application.

Checking items include: UTP, U-malb, U-TRF, U-IGG, β 2-microglobulin, α1-microglobulin, α2-macroglobulin, κ light chain, λ light chain, U- NAG, U-GGT, and Uosm.

▪ Uremic Toxins Tests of Kidney Disease. Aims: 1) Make the buildup of toxins in the body clear; 2) guide the choice of immune clearance method.

Checking items include: BUN, Creatinine, UA, β 2-microglobulin, Cyc C, RBP, HCY, and PTH.

▪ Hematuria Position. Aims: 1) judge the source of RBCs in the urine, glomerular or urinary tract; 2) make the degree of hematuria clear; 3) guide the clinical treatment and medicine application.

Glomerular hematuria:

flow urinary sediment non-uniformity red blood cells; urinary red blood cells form deformation (red blood cells>75%); ALB/UTP 0.73±0.11.

Non-Glomerular hematuria:

flow urinary sediment uniformity red blood cells; urinary red blood cells form deformation (red blood cells<50%); ALB/UTP 0.41±0.14.

Mixed hematuria:

both non-uniformity red blood cells and uniformity red blood cells are detected in the urine.

▪ Tests for sub-group of lymphocytes. It contains 15 indexes to indicate the antibody conditions in your blood, such as CD4, CD8, NK cells, B cells, T Cells etc. Each of them can reflect a specific factor of your immune functions. They are used to: 1) monitor the medical condition after kidney transplant; 2) help your doctor decide the type and amount of immunosuppressive agents; 3) decide when and how to change your immunosuppressive agents.

▪ Complement tests. The tests include C3, C4, CH50, C3B etc. They serve to help your doctors to hold a clear overview of classical pathway and specific pathway of complement, which can deal with the underlying immune disorder.

If you have been diagnosed with IgA Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

iga nephropathy knowledge

IgA Nephropathy and pregnancy

Many women with IgA Nephropathy have conceived successfully. However, whether you can get pregnant depends on your individual conditions. Factors that may increase your risk mainly include high amount of protein in urine, high blood pressure and seriously reduced renal function.

Usually, IgA Nephropathy is associated with the adverse outcomes for both mother and fetus. The possible risks for fetus mainly include fetal prematurity, low birth weight, etc. The adverse outcomes for mother include preeclampsia, eclampsia etc.

If you have decided to get pregnant, you should be referred to an obsterician who specializes in higher risk pregnancies.

IgA Nephropathy and hereditary

Some studies show that IgA Nephropathy has certain genetic predisposition. However, it is relatively rare for the disease to occur in more than one family member. More than 90% of IgA Nephropathy get the disease occasionally without no family history. The rest 10% of patients have a trend of family gathering. Moreover, the morbidity of the disease seems to be higher in certain areas, such as the south part of United States, France and Italy.

Additionally, IgA Nephropathy is more common in certain races. For example, Asian and Hispanics are more likely to have the disease than American Indians.

IgA Nephropathy and Renal Failure

Whether the patients with IgA Nephropathy will develop Renal Failure is very vague. You may develop renal failure in a short time or you maybe never. The following factors can increase your risk significantly:

Uncontrolled high blood pressure

High cholesterol

Large amount of protein in urine

Frequent episodes

If you have been diagnosed with IgA Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

iga nephropathy health care

While receiving effective treatment of IgA Nephropathy, patients should pay attention to the daily care, because a healthy lifestyle can also prevent IgA Nephropathy from developing into Uremia. The following are some useful suggestions for your reference.

·Prevention of inflammatory diseases.

Try to prevent inflammatory diseases such as upper respiratory tract infection, urinary tract infection, skin infection, intestinal tract infection and fungus infection. Once there is infection, you should take measures to stop it as soon as possible.

·Balance between work and rest

Avoid over-strain and strenuous exercise, both of which are factors that may result in aggravation of the disease. It is necessary to have enough rest and proper physical activities in the daily life.

·Eat a proper diet.

People should arrange daily diets according to the specific symptoms. In general, the diet should be low in sodium, protein, fat, potassium and phosphorus.

·Self-monitor

Pay attention to control the blood pressure, observe the change of urine volume, and avoid inducements of hematuria.

·Keep a positive attitude toward life.

A good mood is important to your recovery. Don't be too worried and afraid. You should have confidence to overcome the disease.

If you have been diagnosed with IgA Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

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