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Lupus nephritis refers to inflammation of the kidney caused by systemic lupus erythematosus (SLE),a disease of the immune system.In histology, lupus nephritis can be divided into six stages.How is stage 4 lupus nephritis prognosis?
Stage 4 lupus nephritis is also called diffuse proliferative lupus nephritis. It is both the most severe, and most common subtype. In this stage, more than 50% of glomeruli are involved.The kidney lesions can be segmental or global, active or chronic. In clinic, hematuria and proteinuria are present, frequently with Nephrotic Syndrome. Also, creatinine level starts to elevate.
The following risk factors can worsen the prognosis of stage 4 lupus nephritis significantly.
As stage 4 lupus nephritis is featured by diffuse proliferative lesion in kidneys,a large amount of proteins can leak into urine.Heavy protein in urine is a dangerous factor in worsening the prognosis.
High blood pressure
High blood pressure can increase renal blood flow,which can cause extra strain on kidneys.Controlling blood pressure at target level 130/80mmHg can slow the disease progression.
How to improve prognosis of stage 4 lupus nephritis?
Of course, treatment plays the key role in affecting the prognosis of stage 4 lupus nephritis.There are too forms of drug therapy for lupus nephritis” corticosteroids to control inflammation,and cytotoxic or immunosuppressive drugs to suppress the activity of immune system. However, long-term use of these drugs can cause a number of side effects such as puffy face, increased appetite, cataracts, Diabetes and infection.
Additionally,these drugs alone can not prevent the relapse of the disease. Frequent relapses can worsen the prognosis of stage 4 lupus nephritis significantly.
To improve the prognosis of stage 4 lupus nephritis, an effective treatment is required.Immunotherapy is an alternative treatment for lupus nephritis. It can treat the disease by rebuilding normal immune system and improving renal function. Thus, it can improve the prognosis of lupus nephritis fundamentally.