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Life Expectancy of People with Membranous Nephropathy

Provided by Expert Zhang Youkang on 2012-11-23 17:21

What is the expected life expectancy of people with membranous nephropathy? It is frequently asked by people with the condition. In fact, it is not certain whether their life expectancy is shorter than that of an age-matched healthy population, but some factors actually can influence its prognosis.

Nephrotic syndrome

Some studies suggest that longstanding nephrotic syndrome is associated with a shortened life expectancy in patients with membranous nephropathy. Nephrotic syndrome is a syndrome featured with serious swelling, hyperlipidaemia and hypoproteinemia. Generally, if the proteinuria keeps above 1g/d persistently, it can worsen the prognosis of membranous nephropathy significantly.

High blood pressure

High blood pressure can put extra burden on kidney tissues and cells. Over time, it can impair nephrons. Therefore, it is important to control blood pressure with medications effectively and timely. ACE inhibitors and ARB drugs are commonly used to treat high blood pressure. These medications not only are effective in lowering blood pressure, but also have function in preserving residual renal function.

Renal insufficiency

If renal insufficiency has occurred when membranous insufficiency is diagnosed, the condition indicates a poor prognosis. Additionally, the levels of GFR and necrotic degree of renal tubule also can influence its prognosis significantly.


Treatment is an important controllable factor in affecting the expectancy of people with membranous nephropathy. Conservative treatments for membranous nephropathy mainly include medications for high blood pressure, immunosuppressive drugs and hormones. These treatment are effective in relieving symptoms, but can not eliminate its underlying causes.

Immunotherapy is a new treatment option for membranous nephropathy. It can suppress the inflammation in kidneys, correct the immune dysfunction as well as stimulate the regeneration of impaired kidney structure. In this way, it can control the condition completely so the patients can have a normal life expectancy like healthy persons.

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