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What Is the Prognosis of Henoch-schonlein Purpura Nephritis

Provided by Expert Zhang Youkang on 2013-01-04 11:10

Henoch-schonlein purpura (HSP) is a common vasculitic disease in children by the presence of IgA dominant immune deposits in the small vessels. When the tiny blood vessels in kidneys are involved, it will cause Henoch-schonlein purpura nephritis. What is the prognosis of Henoch-schonlein purpura nephritis?

The prognosis of Henoch-schonlein purpura nephritis varies from case to case as it is determined by many factors.


Frequent relapses indicate a poor prognosis. It can worsen renal function significantly. Every relapse can trigger the abnormal inflammation in kidneys, thus aggravating renal function. Therefore, even if your condition keeps stable, you still need to go to see a doctor and do monitoring regularly.


Heavy protein in urine implies a poor prognosis of Henoch-schonlein purpura nephritis. Excessive protein in urine has toxic effects on kidney tissues and cells and can impair kidney structure significantly. Generally speaking, controlling protein in urine less than 1 g/d can improve the prognosis of the condition.

Extrarenal symptoms

Henoch-schonlein purpura can involve other multiple organs and tissues except for kidneys. Abdominal pain, gastrointestinal bleeding, severe bowel angina etc are commonly noticed. These associated symptoms can worsen the prognosis of Henoch-schonlein purpura nephritis significantly.


Treatment plays a key role in affecting the prognosis of Henoch-schonlein purpura nephritis. Immunosuppressive drugs and hormone only can control the symptoms of the condition, but are unable to eliminate the immune complexes in kidneys or correct immune dysfunction. Immunotherapy is an alternative therapy for Henoch-schonlein purpura nephritis. It can treat the condition from its underlying causes and control it completely, thus resulting in a good prognosis.

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