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How Does Amyloidosis Cause Renal Disease

Provided by Expert Zhang Youkang on 2012-10-26 11:43

Amyloidosis can affect various organs, such as kidney, heart, liver and stomach etc. And once your kidneys are affected, it is called as renal amyloidosis. How does amyloidosis cause renal disease? There are 3 major causes.

According to the different causes, the amyloidosis can be divided into 2 types.

Primary renal amyloidosis

Primary amyloidosis is triggered when the body’s antibody-generating cell do not function well and generate abnormal protein fibers made of antibody fragments. The common condition of primary amyloidosis is multiple myeloma. The antibody fragments come together to form amyloid deposits in different organs, including the kidneys, where they cause serious damage.

Damaged kidneys can't function effectively and may be unable to remove urea and other wastes from the blood. Elevated levels of these protein fibers can also damage the heart, lungs, brain, and digestive system, leading to various discomforts.

Dialysis -related Renal Amyloidosis

Kidneys work to filter the blood and remove the excessive small proteins from the blood. This helps the blood levels stay normal. Dialysis is recommended, when the kidneys are failed or cannot work properly. When patients are getting this kidney replacement treatment, beta-2-microglobulin usually builds up in the blood. And once these beta-2 small proteins join together, they will from a few very large molecules which may deposit on the kidneys, causing renal amyloidosis.

The treatment for renal amyloidosis is suggested as Immunotherapy, because the immunoglobulin is related to underlying immune disorder. Immunotherapy helps regulate the underlying problem and prevent the further complications of Renal Amyloidosis. For more information, you can leave us a message and we will give a feedback very soon.

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