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Renal Amyloidosis

renal amyloidosis basics

What is Renal Amyloidosis?

Renal Amyloidosis is characterized by numerous amyloid fibers depositing on the renal tissues. It is a secondary kidney disease which means that the renal damage is caused by a primary disease-amyloidosis.

The amyloid fiber is a type of amorphous transparent substance like the glass. It includes amyloid protein, amyloid protein A, prealbumin, etc. Macrophages are the main cells that can produce and decompose the amyloid fiber. When macrophages fail to work adequately to eject protein, amyloid fibers will present and build up on tissues of the kidneys.

Pathogenesis of Renal Amyloidosis

Amyloidosis can be caused by a disordered immune system or be the complication of general disorder such as neoplastic disease, infectious disease and immunological disease. About 3/4 cases of secondary amyloidosis will progress to Renal Amyloidosis; while only 1/4 cases of primary amyloidosis may develop into Renal Amyloidosis.

In the condition of immune dysfunction, proteins are not able to be resolved as normal but collect in the tissues, forming amyloid fiber. The renal tissues will consider amyloid fiber as foreign invaders, so inflammation will present in order to clear away the amyloid fiber. Consequently, instead of removing the amyloid fiber, renal intrinsic cells are damaged due to the inflammation. Hence, patients will experience protein or blood in the urine, then developing into renal fibrosis or even Kidney Failure.

If you have been diagnosed with Renal Amyloidosis, we're here to help. Call us: +86-311-86954186 OR email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

Renal Amyloidosis does not cause symptoms in the early stage. With the development of illness condition, the following symptoms may occur. Once detect one or more of these conditions, patients may need to have effective treatment as soon as possible to avoid further damage.

renal amyloidosis symptoms

·Foamy urine due to protein in the urine (proteinuria)

·Swelling (edema) of the eyelids, the lower limbs and the whole body

·Hypertension (high blood pressure)

·Enlargement of tongue (amyloid macroglossia)

·Hypoalbuminemia

·Hyperlipidaemia

·Blood in the urine

·Pain in the abdomen, loin and back pain

·Feeling of sick

·Bad appetite

If you have been diagnosed with Renal Amyloidosis, we're here to help. Call us: +86-311-86954186 OR email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

renal amyloidosis treatment

Renal Amyloidosis treatment options developed over the past few years include Traditional Chinese Medicine, Dialysis, Kidney Transplant, immunotherapy etc.

What kind of treatment you need depends on your individual conditions, including which amyloid protein you have, how this abnormal protein affects your kidney tissues and you general health status etc.

Traditional Chinese Medicine

Some plant compounds have the natural ability to combat the damage done to the body free radicals and the process of oxidation as well as inflammation.

In some cases, Chinese herbs have provided complete treatment for the Amyloidosis and in other cases they have been utilized to support standard medical care.

Besides Amyloidosis, TCM helps repair the damaged kidney tissues and improve kidney function.

Immunotherapy

Immunotherapy is a biotherapy which rebuilds a normal immune system and use the immune system to fight against the disease. Before treatment plan, your doctor will give you some special tests that relates to your immune system and kidney damages, which help find which amyloid protein you have and what the kidney damage condition is. This helps your doctor to choose right immunotherapy to cleanse out the abnormal protein and repair the specific damaged tissues.

Dialysis

Dialysis may be not the best treatment option for renal Amyloidosis, because dialysis can increase the risk of developing Amyloidosis. Patients on dialysis do not have functioning kidneys, and the dialysis machinery is unable to remove the protein that causes the disease.

Kidney transplant

Kidney transplant is a therapy which uses a donated kidney to replace the failed kidneys. Kidney transplant only cannot deals with the disease well and blood purification should be used to remove the abnormal protein in your blood. After the transplantation, you need to take drugs to prevent the new kidney being attacking by immune system.

If you have been diagnosed with Renal Amyloidosis, we're here to help. Call us: +86-311-86954186 or email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

renal amyloidosis test

How to know your kidneys have been damaged by amyloidosis? Proteinuria, blood in urine, swelling, hypoproteinemia are the symptoms that can indicate that your kidney tissues have been damaged. Besides, a series of lab tests need to be done to confirm the diagnosis of Renal Amyloidosis.

1. Immune special examination

▪ Test of M-protein. This is an important diagnostic criteria of this disease which contains several tests: 1) serum protein electrophoresis and immune electrophoresis are used to diagnose and confirm the type of M-proteinemia. 2) quantify serum Ig: large amounts of monoclonal immunoglobulin (M-protein) occur in certain serum Ig (IgG>35g/l; IgA>20g/l; IgD>2.0g/l; IgE>2.0g/l; IgM>15g/l). Other kinds of Ig decrease obviously or keep normal amounts. 3) Urine sample-Bence-Jones protein test: positive result indicate that there is free immune globulin light chain in the urine. This is an index of light chain disease diagnosis.

▪ Kidney Damage Tests. Aims: 1) confirm the kidney damage; 2) the damaged part, glomerulus or renal tubules; 3) make the severity of kidney damage clear and guide the clinical choice of medicine; 4) judge patient's sensitivity to medicines and guide the clinical medicine application.

Checking items include: UTP, U-malb, U-TRF, U-IGG, β 2-microglobulin, α1-microglobulin, α2-macroglobulin, κ light chain, λ light chain, U- NAG, U-GGT, and Uosm.

▪ Toxins in Blood Tests of Kidney Disease. Aims: 1) Make the buildup of toxins in the body clear; 2) guide the choice of immune clearance method.

Checking items include: BUN, Creatinine, UA, β 2-microglobulin, Cyc C, RBP, HCY, and PTH.

2. General special examination

·Series of blood fat test. Aims: 1) judge whether patent's blood fat level has become elevated or the degree of increasing; 2) types of hyperlipidemia; 3) guide the clinical clearance method of blood fat. It can be divided into 7 check items of blood fat (triglyceride, total cholesterol, HDL, LDL, Apo A1, Apo BT, lipoprotein a) and 9 check items of blood fat.

·9 check items of blood fat. Checking items include: BUN, Creatinine, UA, β 2-microglobulin, Cyc C, RBP, HCY, PTH, Apo E and free fatty acids.

Abnormally elevated serum Apo E level is the most featured index of lab test for lipoprotein glomerulopathy. Serum free fatty acids can reflect the human body fat metabolism and blood fat level. It is also an important substance that causes insulin resistance, which has significant meaning for clinical diagnosis of Diabetes and decrease risk factor of cardiovascular disease.

·Series of sugar metabolism test. Aim: index to judge the dysfunction of human body metabolism; produce index for clinical treatment and treatment effect, including blood sugar, HbA1c, insulin, and C-peptide.

Blood sugar reflect the level of glucose in the blood. HbA1c reflects the averaged level of blood sugar in recent three months. Insulin and C-peptide reflect human body's adjustive ability of sugar metabolism. Sugar metabolism dysfunction may accelerate the progression of kidney disease.

If you have been diagnosed with Renal Amyloidosis, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

renal amyloidosis knowledge

Renal Amyloidosis is a typical secondary kidney disease which is caused by an abnormal protein. If you happen to be a person with renal Amyloidosis, the following topic may be helpful for you, including pregnancy, sexual life and lifespan.

Renal Amyloidosis and Pregnancy

Renal Amyloidosis is not suggested to have a baby, if your medical condition is not good. Pregnancy will overload the poor kidney, leading to progressive kidney function decline. This may put the mother-to-be and fetus into dangers. If the condition cannot be controlled well, it may lead to miscarriage.

Preparation for the Pregnancy

If your kidney function is not low and your condition is stable, you may suggest to have a baby. However, you should prepare well for pregnancy.

- visit your doctor at regular basis

- stop medicine for 3 years before you plan to have a baby

- manage well diet and lifestyle

Renal Amyloidosis and sexual life

Some female patients may suffer from hip pain and dryness which may be troubles in sexual life. Besides the physical problems, most patients appear to have negative mind during their sexual time. Sometimes, patients may develop a negative self-image and lose confidence that affects sexual life.

Renal Amyloidosis and Lifespan

There exists no standard lifespan for renal Amyloidosis. Lifespan varies from person to person and it mainly depends on the following factors.

- your general medical condition

- your symptoms and complication

- the treatment you are taking

- the lifestyle you are keeping

If you have been diagnosed with Renal Amyloidosis, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

renal amyloidosis healtcare

Living a healthy lifestyle is a part of treatment for patients with Renal Amyloidosis, which can bring double effects for improving their kidney function and alleviating the disease symptoms. Here are some suggestions for your reference.

·Follow a balanced diet. Balanced nutrition is important to provide patient's body with an adequate energy supply.

High-protein diet. It is better and healthier to choose the fat-free part of poultry without skin like chicken breast. Good sources of protein also include fish, dairy products, eggs, milk, etc. Avoid bean and bean products, because the potassium and phosphorus contained in them cannot be removed by the impaired kidneys.

Diet low in salt. The intake of salt can be limited to less than 3g each day. Avoid processed foods from shops. Replace salt with some flavoring such as fruit juices, vinegar or herbs in order to increase the appetite.

Low-potassium diet. Do not eat fruits and vegetables that are rich in potassium, such as bananas, prunes, apricots, dates, strawberries, raisins,watermelon, beets, citrus fruits and so on.

Take proper exercises to improve the immune system and benefit the damaged kidneys. Instead of strenuous sports or any other body contact activities, patients are suggested to take some mild exercises. Choose continuous activities, such as walking, swimming, bicycling, skiing, yoga, aerobic dancing or other exercises that you need to move large muscle groups constantly. Discuss with the doctor about the type of exercises, how often you exercise, how hard you work while exercising and the length of time you spend exercising, etc.

Pace yourself. Take a break if you feel short of breath. You may be able to continue normal daily activities, such as going to work. Talk to your doctor about what's an appropriate level of activity for you.

If you have been diagnosed with Renal Amyloidosis, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

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